10 Additionally, endothelial ROBO4 mutation or deficiency in mice results in TAA formation with a bicuspid aortic valve. For example, the endothelial angiotensin type 1 receptor is responsible for aneurysm formation in Fbn1 mgR/mgR mice, 9 while endothelial ADAM17 contributes to elastase‐induced TAAs by disrupting endothelial junctions. ![]() 7, 8 More recently, the contribution of vascular endothelial cells (ECs) has been reported as a crucial factor in TAA pathogenesis. 5, 6 On this basis, therapeutic strategies targeting SMCs with angiotensin type 1 receptors have been developed however, their efficacy over conventional medications (eg, β‐blockers) has not been confirmed in human patients. 3, 4 Mutations in extracellular matrix (ECM) proteins and SMC contractile proteins are also related to the development of TAAs. 2 TAAs can be associated with heritable diseases with syndromic features, (eg, Marfan syndrome and Loeys‐Dietz syndrome) and exhibit the marked activation of transforming growth factor β (TGF‐β) and mitogen‐activated protein kinase signaling in vascular smooth muscle cells (SMCs). 1 Surgical resection or stent graft insertion is commonly performed as a prophylactic measure against aortic rupture however, effective medications to halt or reverse TAA progression have yet to be established. TAAs typically progress asymptomatically and can be life‐threatening when they rupture or dissect. Thoracic aortic aneurysm (TAA) refers to an irreversible enlargement of the aortic wall that exceeds 1.5 times the normal aortic diameter. Nonstandard Abbreviations and Acronyms α‐SMA Furthermore, RNA sequencing and immunostaining of the aortic valve revealed the upregulation of genes involved in endothelial‐to‐mesenchymal transition, inflammatory response, and tissue fibrosis in DKO valves and the presence of activated valve interstitial cells. DKO mice also showed progressive aortic valve thickening with collagen deposition from postnatal day 14, as well as turbulent flow in the ascending aorta. DKO mice showed the exacerbation of thoracic aortic aneurysms when compared with those of SMKO and upregulated Thbs1, a mechanical stress–responsive molecule, throughout the aorta. Knockdown of FBLN4 in human aortic ECs induced mesenchymal cell–like changes with the upregulation of mesenchymal genes, including TAGLN and MYL9. An evaluation of the thoracic aortic aneurysm phenotype and screening of altered signaling pathways were performed. ![]() Fbln4 double knockout ( DKO) mice in ECs and smooth muscle cells were generated and subjected to histological analysis, echocardiography, Western blotting, RNA sequencing, and immunostaining. Gene silencing of FBLN4 was conducted on human aortic ECs to evaluate morphological changes and gene expression profile. Stroke: Vascular and Interventional Neurology.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).
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Great overall gaming sound - with some caveats We’re big fans of the Xbox Wireless Headset’s minimalist approach to controls, though a button for switching between sound presets (which we’ll get to later on) would have been handy. Pairing was also painless, as we were able to connect to our Xbox, phone and PC within seconds. The dials are a great touch, and we found them much more intuitive than the often tiny volume knobs tucked between a sea of buttons on many gaming headsets. There’s also a power/pairing button and a mute button for when you don’t want your Call of Duty teammates to hear you munching on snacks. The Xbox Wireless Headset keeps things simple with on-ear controls, taking a page out of the Surface Headphones 2 playbook with a large rotating dial on each ear - one for adjusting overall volume, and another for adjusting the mix between game and voice chat volume. 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Like the Xbox Series X console that it’s inspired by, the Xbox Wireless Headset has an unassuming design built to blend into your gaming den or home office. If you want something sleeker, the Arctis 1 Wireless is worth considering. ![]() How it compares: The Xbox Wireless Headset is similar in price and functionality to the $99 Turtle Beach Stealth 600 Gen 2 and $99 SteelSeries Arctis 1 Wireless, but only Microsoft’s headset has Bluetooth for pairing to your console and phone at the same time. This way, you can listen to podcasts and take calls while still hearing the sounds of your favorite games. What you need to know: Microsoft’s new gaming headset delivers impressive audio within a very comfortable design, but the real standout is its ability to pair to your Xbox and phone at the same time. Who it’s for: The Xbox Wireless Headset is for Xbox and PC gamers seeking an affordable, good-sounding gaming headset that also plays nice with smartphones. ![]() Is the Xbox Wireless Headset a must-have for Xbox gamers? Here’s what we think after several days of working, playing and chatting with it strapped to our head. And that’s on top of the fact that Microsoft’s new headset sounds great for games and is comfortable enough to wear all day long - all for an enticing $99. Now, we’re not trying to encourage you to zone out during an important meeting to play some Halo, but being able to have a single headset for work and play without having to constantly reconnect any devices is a huge boon. That’s because in addition to instantly pairing to your Xbox, it can also sync up to your phone or PC at the same time to let you take calls or listen to podcasts while you game. The Xbox Wireless Headset just might be the ultimate gaming headset for a work-from-home world. Your CNN account Log in to your CNN account ![]() That's the fastest way to get the changes to work for you. This restarts Cinnamon, which applies the settings you have or are editing. Additionally, several penetration tools have been included. When you are running Cinnamon, at least on Linux Mint, the inventors of Cinnamon, you only need to use ALT-F2 and type the command 'r' (sans quotes) and press ENTER. To improve the security aspect of the distribution, servers have been removed, incoming ports closed and services turned off. This can be launched from the Desklet itself by selecting Config from the menu. The size and format of the date are configurable by changing the values in metadata.json. URIX OS (formerly NetSecL) was a security-focused distribution and live DVD based on openSUSE. A fork desklet that displays the time and date README Close Time and Date Cinnamon Desklet v0.1 - 19 June 2013 This is a simple desklet to display the time and date. Open Source Security Podcast - 369 ( MP3) WhatsApp Business vs 3CX WhatsApp API Integrationĭon’t be “THAT” Guy Vol.1: Keep Complex Credentialsĭon’t be “THAT” Guy Vol.3: Top 4 Security Tipsĭon’t be “THAT” Guy Vol.4: Monitor Your Instance Lubuntu and Ubuntu Studio absent from recent Ubuntu community spin updatesĭebian has one candidate for Project Leaderĭon't Get Caught Out, Make a Disaster Recovery Plan!Įssential Live Chat Reports and Statistic Ubuntu Cinnamon becomes an official Ubuntu edition The Mint team is updating icons and themesĮndeavourOS plans new theme, installer and welcome utility Shared resources are also examined, including the CUPS printing server, the NFS Linux network file server, and Samba Windows file server.Get 3CX StartUP, your small business phone systemĮlementary OS improves sideloading experienceįedora plans to provide more encryption by default It aims to live fast as well as lightweight, piece even as well as thus existence visually appealing as well as slow to use. In addition, configuration of wired and wireless connections, firewalls, and service management using systemd are covered. XFCE is a gratis software desktop surroundings for Unix as well as Unix-like platforms, such every bit Linux, Solaris, as well as BSD. Administration topics include system tools, managing users, file systems, Bluetooth setup, printer configuration, and network folder and file sharing. ![]() Mint 18.2 Cinnamon, Quad core AMD A8-3870 with Radeon HD Graphics 6550D, 8GB DDR3, Ralink RT2561/RT61 802. Desklets created for Cinnamon 1.8 will not work. The Linux Mint X-Apps are also reviewed, including Xplayer, Xed, and Xviewer. If you are using older desklets which have not been upgraded to be compatible with Cinnamon 2.4.5 you will have problems. most useless crap i ever installed on my mint 15. The program may be useless, but for me, it DOES work 'out of the box'. They do not work at all with Linux Mint 19.3 Tricia - Debian/Ubuntu. Advanced components are also examined such as the LightDM Display Manager, NetworkManager, the Samba server, and Mint software management applications (Software Manager and Update Manager). I installs just fine and seems to do what it says it will. Most of these Applets and Desklets for Linux are in bad need of a serious update. Cinnamon and Mate have custom Mint menus to manage access to applications and devices. the cryptocurrency desklet to show your cryptocurrency portfolio value or. The Cinnamon and Mate desktops are examined in detail. It'd be great if desklets could be bound to a workspace, meaning: a desklet would only be visible on workspace 1, but not on workspace 2, 3, 4, etc. You get to finish your chores faster than ever and leave your computer satisfied as you shut it off for the next cycle. What they are intended for is to get your focus-on-work and rely on the information the Desklet accesses for you. 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